Abstract
Recent advances in cancer molecular biology have resulted in parallel and unprecedented progress in the development of targeted cancer therapy. Targeted therapy can provide higher efficacy and lower toxicity than conventional chemotherapy for cancer. However, like traditional chemotherapy, molecularly targeted cancer therapy also faces the challenge of drug resistance. Multiple mechanisms are responsible for chemotherapy resistance in tumors, including over-expression of efflux transporters, somatic alterations of drug targets, deregulation of apoptosis, and numerous pharmacokinetic issues. Nanotechnology based approaches are proving to be efficacious in overcoming drug resistance in cancer. Combination of targeted therapies with nanotechnology approaches is a promising strategy to overcome targeted therapy drug resistance in cancer treatment. This review discusses the mechanisms of targeted drug resistance in cancer and discusses nanotechnology approaches to circumvent this resistance.
Keywords: Drug resistance, nanotechnology, targeted cancer therapy.
Current Medicinal Chemistry
Title:Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance
Volume: 22 Issue: 11
Author(s): Yan Gao, Jacson K. Shen, Lara Milane, Francis J. Hornicek, Mansoor M. Amiji and Zhenfeng Duan
Affiliation:
Keywords: Drug resistance, nanotechnology, targeted cancer therapy.
Abstract: Recent advances in cancer molecular biology have resulted in parallel and unprecedented progress in the development of targeted cancer therapy. Targeted therapy can provide higher efficacy and lower toxicity than conventional chemotherapy for cancer. However, like traditional chemotherapy, molecularly targeted cancer therapy also faces the challenge of drug resistance. Multiple mechanisms are responsible for chemotherapy resistance in tumors, including over-expression of efflux transporters, somatic alterations of drug targets, deregulation of apoptosis, and numerous pharmacokinetic issues. Nanotechnology based approaches are proving to be efficacious in overcoming drug resistance in cancer. Combination of targeted therapies with nanotechnology approaches is a promising strategy to overcome targeted therapy drug resistance in cancer treatment. This review discusses the mechanisms of targeted drug resistance in cancer and discusses nanotechnology approaches to circumvent this resistance.
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Cite this article as:
Gao Yan, Shen K. Jacson, Milane Lara, Hornicek J. Francis, Amiji M. Mansoor and Duan Zhenfeng, Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance, Current Medicinal Chemistry 2015; 22 (11) . https://dx.doi.org/10.2174/0929867322666150209151851
DOI https://dx.doi.org/10.2174/0929867322666150209151851 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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