Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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Diazenyl Derivatives as Therapeutic and Diagnostic Agents Acting on Central Nervous System

Author(s): Harmeet Kaur, Snehlata Yadav, Balasubramanian Narasimhan.

Graphical Abstract:


Abstract:

In last decade, the development of new drugs and drug products for central nervous system (CNS) has remained limited due to incomplete elucidation of pathophysiology of many CNS disorders, complexity of the diseases and the lack of technologies for delivery through the blood-brain barrier (BBB). In this article we will summarize the development of diazenyl derivatives of many biologically active moieties like benzodiazepine, formazan, indole, pyrimidine, thiazole, sulfonamide etc. as diagnostic and therapeutic agents for CNS. The potential of already existing azo compounds as potent CNS agents have also been discussed. This overview will provide the researchers an opportunity for further development of new diazenyl derivatives in CNS area.

Keywords: CNS activities, diazenyl derivatives, diagnostic.

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Article Details

VOLUME: 15
ISSUE: 1
Year: 2015
Page: [42 - 51]
Pages: 10
DOI: 10.2174/1871524915666150209123729