Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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1,2,4-Triazole Derivatives as Potential Scaffold for Anticonvulsant Activity

Author(s): Vipan K. Kamboj, Prabhakar K. Verma, Anu Dhanda, Sudhir Ranjan.

Graphical Abstract:


Abstract:

The search for new anticonvulsant agent with more selectivity and lower toxicity continues to be an area of rigorous investigation in medicinal chemistry. Epilepsy is a chronic disorder of brain whose treatment consists of controlling seizures with antiepileptic drugs that very often related with side-effects which in rare circumstances can be potentially life-threatening. Triazolam and Alprazolam are established drugs used in epilepsy which have triazole moiety. The potency and broad spectrum of the pharmacological response of triazole moiety as anticonvulsant agent have attracted the attention of medicinal chemists to explore this framework for its potential. The literature shows that different substitution on triazole ring exhibit potent antiepileptic activity with no or lesser neurotoxicity. The present review is a sincere attempt to compile the reported potent triazole derivatives with significant anticonvulsant action.

Keywords: Anticonvulsant activity, epilepsy, 1, 2, 4-triazole, seizure, neurotoxicity.

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Article Details

VOLUME: 15
ISSUE: 1
Year: 2015
Page: [17 - 22]
Pages: 6
DOI: 10.2174/1871524915666150209100533