Mono or di-substituted prolines, namely proline chimeras of natural or synthetic origin,
carry the side chain of other specific amino acids on the pyrrolidine ring. Thus, proline chimeras are
useful tools for a wide range of chemical and biological applications as chiral synthons or building
blocks for peptidomimetic design. We focused our attention on domoic acid and kainic acid and we
report here a concise and up to date review on their stereoselective and asymmetric syntheses.
Keywords: Asymmetric synthesis, building blocks, domoic acid, kainic acid, proline chimeras.
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