CYP1B1, a recently described dioxin inducible oxidoreductase, is a member of the cytochrome P450 superfamily involved in
the metabolism of estradiol, retinol, benzo[a]pyrene, tamoxifen, melatonin, sterols etc. It plays important roles in numerous physiological
processes and is expressed at mRNA level in many tissues and anatomical compartments. CYP1B1 has been implicated in scores of disorders.
Analyses of the recent studies suggest that CYP1B1 can serve as a universal/ideal cancer marker and a candidate gene for predictive
diagnosis. There is plethora of literature available about certain aspects of CYP1B1 that have not been interpreted, discussed and philosophized
upon. The present analysis examines CYP1B1 as a peculiar gene with certain distinctive characteristics like the uniqueness in
its chromosomal location, gene structure and organization, involvement in developmentally important disorders, tissue specific, not only
expression, but splicing, potential as a universal cancer marker due to its involvement in key aspects of cellular metabolism, use in diagnosis
and predictive diagnosis of various diseases and the importance and function of CYP1B1 mRNA in addition to the regular translation.
Also CYP1B1 is very difficult to express in heterologous expression systems, thereby, halting its functional studies. Here we review
and analyze these exceptional and startling characteristics of CYP1B1 with inputs from our own experiences in order to get a better insight
into its molecular biology in health and disease. This may help to further understand the etiopathomechanistic aspects of CYP1B1
mediated diseases paving way for better research strategies and improved clinical management.
Keywords: CYP1B1, cytochrome, drug metabolism, functional genomics, gene expression, glaucoma, ideal cancer marker, pharmacogenomics,
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