Bone Regeneration with Biomaterials and Active Molecules Delivery

Author(s): Matteo D`Este, David Eglin, Mauro Alini, Laura Kyllonen.

Journal Name: Current Pharmaceutical Biotechnology

Volume 16 , Issue 7 , 2015

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Abstract:

The combination of biomaterials and drug delivery strategies is a promising avenue towards improved synthetic bone substitutes. With the delivery of active species biomaterials can be provided with the bioactivity they still lack for improved bone regeneration. Recently, a lot of research efforts have been put towards this direction. Biomaterials for bone regeneration have been supplemented with small or biological molecules for improved osteoprogenitor cell recruitment, osteoinductivity, anabolic or angiogenic response, regulation of bone metabolism and others. The scope of this review is to summarize the most recent results in this field.

Keywords: Biomaterials, bone defects, bone regeneration, drug delivery, growth factors, scaffolds, small molecules, synthetic bone substitutes.

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Article Details

VOLUME: 16
ISSUE: 7
Year: 2015
Page: [582 - 605]
Pages: 24
DOI: 10.2174/1389201016666150206112121
Price: $58

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