Abstract
Transcutaneous vaccination has become a widely used technique for providing immunity against several types of pathogens, taking advantage of the immune components found in the skin. The success in the field of vaccination has not only relied on the type of antigen and adjuvant delivered, but also on how they are delivered. In this regard, particulate carriers, especially nanoparticles have evoked considerable interest, owing to the desirable properties that they impart to the substance being delivered. The presentation of antigens by the nanoparticles mimics the presentation of the immunogen by the pathogen; hence, it creates a similar immune response. Furthermore, nanoparticles protect the antigen from degradation and allow its prolonged release, which maximizes its exposure to the immune cells. The most commonly used materials for the formulation of nanoparticles are either polymer-based or lipid based. This review will focus on the lipid based nanocarriers, either vesicular such as liposomes, transfersomes, and ethosomes, or non-vesicular such as cubosomes, solid lipid nanoparticles, nano-structured lipid carriers, solid in oil nanodispersions, lipoplexes, and hybrid polymeric-lipidic systems. The applications of these carriers in the field of transcutaneous immunization will be discussed in this review as well.
Keywords: Lipids, skin, immunization, transcutaneous, nanocarriers, vaccines.
Current Pharmaceutical Biotechnology
Title:A Highlight on Lipid Based Nanocarriers for Transcutaneous Immunization
Volume: 16 Issue: 4
Author(s): Maha Nasr, Sameh Abdel-Hamid and Abdullah A. Alyoussef
Affiliation:
Keywords: Lipids, skin, immunization, transcutaneous, nanocarriers, vaccines.
Abstract: Transcutaneous vaccination has become a widely used technique for providing immunity against several types of pathogens, taking advantage of the immune components found in the skin. The success in the field of vaccination has not only relied on the type of antigen and adjuvant delivered, but also on how they are delivered. In this regard, particulate carriers, especially nanoparticles have evoked considerable interest, owing to the desirable properties that they impart to the substance being delivered. The presentation of antigens by the nanoparticles mimics the presentation of the immunogen by the pathogen; hence, it creates a similar immune response. Furthermore, nanoparticles protect the antigen from degradation and allow its prolonged release, which maximizes its exposure to the immune cells. The most commonly used materials for the formulation of nanoparticles are either polymer-based or lipid based. This review will focus on the lipid based nanocarriers, either vesicular such as liposomes, transfersomes, and ethosomes, or non-vesicular such as cubosomes, solid lipid nanoparticles, nano-structured lipid carriers, solid in oil nanodispersions, lipoplexes, and hybrid polymeric-lipidic systems. The applications of these carriers in the field of transcutaneous immunization will be discussed in this review as well.
Export Options
About this article
Cite this article as:
Nasr Maha, Abdel-Hamid Sameh and A. Alyoussef Abdullah, A Highlight on Lipid Based Nanocarriers for Transcutaneous Immunization, Current Pharmaceutical Biotechnology 2015; 16 (4) . https://dx.doi.org/10.2174/1389201016666150206105552
DOI https://dx.doi.org/10.2174/1389201016666150206105552 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Enterovirus D-68 Molecular Virology, Epidemiology, and Treatment: an Update and Way Forward
Infectious Disorders - Drug Targets Rationale of Hyperbaric Oxygenation in Cerebral Vascular Insult
Current Vascular Pharmacology Chemical and Genetic Engineering Strategies to Improve the Potency of Pharmaceutical Proteins and Enzymes
Current Medicinal Chemistry The Recent Progress in RSV Vaccine Technology
Recent Patents on Anti-Infective Drug Discovery Editorial (Thematic Issue: Neuroglia as a Central Element of Neurological Diseases: An Underappreciated Target for Therapeutic Intervention)
Current Neuropharmacology Gene Therapy in the Anterior Eye Segment
Current Gene Therapy Rift Valley Fever Virus
Current Molecular Medicine The Herpesvirus Encoded dUTPase as a Potential Chemotherapeutic Target
Current Protein & Peptide Science Disease-Induced Neuroinflammation and Depression
CNS & Neurological Disorders - Drug Targets Nano-formulations for Diagnostics and Therapeutics of Foot-and-Mouth Disease in Animals
Nanoscience & Nanotechnology-Asia Teenage-Pregnancies - A Biomedical and a Sociocultural Approach to a Current Problem
Current Women`s Health Reviews Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease
Mini-Reviews in Medicinal Chemistry Peptide Vaccine Models Using Statistical Data Mining
Protein & Peptide Letters Plant Phenolic Compounds as Potential Lead Compounds in Functional Foods for Antiviral Drug Discovery
Current Organic Chemistry A Review on Response of Immune System in Spinal Cord Injury and Therapeutic Agents useful in Treatment
Current Pharmaceutical Biotechnology Glycyrrhizic Acid Derivatives as New Antiviral and Immune Modulating Agents
Current Bioactive Compounds State-of-the-Art Lentiviral Vectors for Research Use: Risk Assessment and Biosafety Recommendations
Current Gene Therapy Targeted and Armed Oncolytic Poxviruses for Cancer: the Lead Example of JX-594
Current Pharmaceutical Biotechnology Involvement of Toll-like Receptors in Ischemia-induced Neuronal Damage
Central Nervous System Agents in Medicinal Chemistry Cefepime-Induced Neurotoxicity
Central Nervous System Agents in Medicinal Chemistry