Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Endothelial Progenitor Cells and In-stent Restenosis

Author(s): Bu-Yun Xu, Mei-Xiang Xiang, Jian-an Wang.

Abstract:

Coronary artery disease (CAD) is a significant global health problem, contributing to significant morbidity and mortality. Percutaneous coronary intervention (PCI) is an efficient therapy for treating CAD, but it carries the risk of iatrogenic endothelial injury, which contributes to vessel inflammation and induction of in-stent restenosis. Therefore, developing novel methods for enhancing re-endothelialization after PCI is highly needed. Endothelial progenitor cells (EPCs) can differentiate into mature endothelial cells, and cell therapy with EPC may offer a novel way for accelerating reendothelialization. In this review paper, we aimed to briefly describe EPCs and highlight their potential therapeutic roles in in-stent re-stenosis and endothelial injury.

Keywords: Coronary heart disease, endothelial cell, endothelial progenitor cell, endothelium injury, percutaneous coronary intervention, in-stent restenosis.

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2015
Page: [364 - 371]
Pages: 8
DOI: 10.2174/1574888X10666150204150430
Price: $58