Endochondral ossification is under the regulation of endocrine, paracrine and otocrine factors
including transforming growth factor-β superfamily members, fibroblast growth factors, retinoids, products
of hedgehog gene, parathyroid hormone-related peptide, molecules involved in cell adhesion, and extracellular
matrix components. Natriuretic peptide receptor-B, and its ligand C-type natriuretic peptide
have also been implicated in the regulation of limb bone development. Results of recent studies are promising
in terms of systemic elevation of C-type natriuretic peptide level inducing growth. In addition, same
strategy also overcomes the dwarf phenotype of achondroplasia, the most frequently seen skeletal dysplasia in human, in a
mouse model. Based on this literature and a series of recent experiments discussed here, this perspective underlines the abundant
C-type natriuretic peptide expression in trabecular bone derived mesenchymal stem cells of human, chicken, and rat origin,
and proposes the potential use of mesenchymal stem cells as a part of growth inducing treatment strategy in osteochondrodisyplasias
in the future.
Keywords: Achondroplasia, C-type natriuretic peptide, dwarfism, endochondral ossification, mesenchymal stem cells, natriuretic
peptide receptor-B, osteochondrodisyplasia, skeletal dysplasia.
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