Some furan-based chalcone derivatives were synthesized via the Claisen-Schmidt
condensation of 5-arylfurfural derivatives with 4'-cyanoacetophenone. The synthesized derivatives
were investigated for their antimicrobial activity using a broth microdilution assay. Among these compounds,
1-(4-cyanophenyl)-3-[5-(4-nitrophenyl)-2-furyl]-2-propen-1-one (4) can be considered as the
most promising antimicrobial agent against Enterococcus faecalis (ATCC 51922) and Candida
albicans. Compound 4 showed antimicrobial activity against E. faecalis with a MIC value of 100 µg/mL, whereas chloramphenicol
exhibited its antibacterial activity with a MIC value of 200 g/mL. Compound 4 (MIC = 100 µg/mL) was
also more effective than ketoconazole (MIC = 200 µg/mL) against C. albicans. Microbiological assay pointed out the importance
of p-nitro substituent for antimicrobial activity.
Keywords: Chalcone, furan, antibacterial activity, anticandidal activity.
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