Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents

Author(s): Ahmet Ozdemir, Mehlika Dilek Altıntop, Zerrin Canturk, Zafer Asim Kaplancikli.

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 7 , 2015

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Graphical Abstract:


Some furan-based chalcone derivatives were synthesized via the Claisen-Schmidt condensation of 5-arylfurfural derivatives with 4'-cyanoacetophenone. The synthesized derivatives were investigated for their antimicrobial activity using a broth microdilution assay. Among these compounds, 1-(4-cyanophenyl)-3-[5-(4-nitrophenyl)-2-furyl]-2-propen-1-one (4) can be considered as the most promising antimicrobial agent against Enterococcus faecalis (ATCC 51922) and Candida albicans. Compound 4 showed antimicrobial activity against E. faecalis with a MIC value of 100 µg/mL, whereas chloramphenicol exhibited its antibacterial activity with a MIC value of 200 g/mL. Compound 4 (MIC = 100 µg/mL) was also more effective than ketoconazole (MIC = 200 µg/mL) against C. albicans. Microbiological assay pointed out the importance of p-nitro substituent for antimicrobial activity.

Keywords: Chalcone, furan, antibacterial activity, anticandidal activity.

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Article Details

Year: 2015
Page: [607 - 611]
Pages: 5
DOI: 10.2174/1570180812999150202112352
Price: $58

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