Abstract
Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.
Keywords: Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.
Anti-Cancer Agents in Medicinal Chemistry
Title:Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?
Volume: 15 Issue: 7
Author(s): Lichun Sun, Guangchun Sun, Yan Yu and David H. Coy
Affiliation:
Keywords: Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.
Abstract: Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.
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Cite this article as:
Sun Lichun, Sun Guangchun, Yu Yan and H. Coy David, Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (7) . https://dx.doi.org/10.2174/1871520615666150202102809
DOI https://dx.doi.org/10.2174/1871520615666150202102809 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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