Anticancer Agents Derived from Natural Cinnamic Acids

Author(s): Ping Su, Yaling Shi, Jinfeng Wang, Xiuxiu Shen, Jie Zhang.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 15 , Issue 8 , 2015

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Graphical Abstract:


Cancer is the most dangerous disease that causes deaths all over the world. Natural products have afforded a rich source of drugs in a number of therapeutic fields including anticancer agents. Many significant drugs have been derived from natural sources by structural optimization of natural products. Cinnamic acid has gained great interest due to its antiproliferative, antioxidant, antiangiogenic and antitumorigenic potency. Currently it has been observed that cinnamic acid and its analogs such as caffeic acid, sinapic acid, ferulic acid, and isoferulic acid display various pharmacological activities, such as immunomodulation, anti-inflammation, anticancer and antioxidant. They have served to be the major sources of potential leading anticancer compounds. In this review, we focus on the anticancer potency of cinnamic acid derivatives and novel strategies to design these derivatives. We hope this review will be useful for researchers who are interested in developing anticancer agents.

Keywords: Anticancer candidates, caffeic acid, ferulic acid, sinapic acid.

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Article Details

Year: 2015
Page: [980 - 987]
Pages: 8
DOI: 10.2174/1871520615666150130111120
Price: $58

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