Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance
Heidi Qunhui Xie,
The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families
with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs
is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The
mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC
transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family,
the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and
physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.
Keywords: ATP-binding cassette (ABC) transporter, cancer, inhibitors, multi-drug resistance, substrate.
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