Fragment-based Designing for the Generation of Novel Leads Against BACE1
BACE1, the aspartate protease that generates amyloid-β peptide (Aβ) in the brain of AD
(Alzheimer’s disease) patients, has emerged as a pharmaceutically relevant target. Here, a fragment-based in
silico approach has been adopted to design novel compounds with increased ligand efficiency for BACE1,
before screening for brain permeability and toxicity. Fragments docked to the active site of BACE1 and
sorted into two groups using binding energy cut-off, were joined to create novel ligands with binding energy
lying in the range between -11.36 kcal/mol and -8.56 kcal/mol. Interestingly, QIN, a known inhibitor of
BACE1 with an IC50 of 11nM, when docked to BACE1, shows a binding energy (-9.43 kcal/mol) lying within the range
of the novel ligand-BACE1 complexes. The present strategy thus enabled the design of four novel inhibitors of BACE1
with favourable binding energy, brain permeability and no toxicity that might show promise as leads in future.
Keywords: BACE1, inhibitors, fragment, binding energy, design.
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