In our previous work, we presented the results of a 12-year study (1998-2010)
from which we derived several important conclusions. This was a large cohort, in which
were examined 3619 samples of umbilical cord blood. We reached several conclusions from
which it was clear that allergy was significantly associated with a positive family history
(statistical significance at 1 ‰). The first symptoms of allergic disease occurred in the first
years of life. We also observed significant seasonal differences. High levels of umbilical IgE
and a positive family history were found to be grounds for preventive intervention by influencing the microbial
flora of the gastrointestinal tract (GIT). We used Colinfant Newborn peroral probiotic vaccine - a lyophilized
non-pathogenic strain of E. coli. The results in 2005-2008 and 2008-2009 confirmed that in treated patients
with primary elevated levels of immunoglobulin E (IgE) in umbilical cord blood, IgE values at one year
of age fully normalized in 90 %. The medical history of these children indicated minimal sickness rates. We
further investigated IgG values at one year of age and compared this with a control group. After treatment
these levels were also normalized. From 2009-2012, we investigated the effect of treatment on the values of
immunoglobulins IgE, IgG, but also IgA, and statistically processed the data at 1 year of age and 3 years of
age. Statistically, a correlation was observed between IgG and IgA in the 1st year of life and at 3rd years of age
with a significance level of 1 ‰. The results show that treatment with Colinfant has a positive effect in the
sense that the resulting IgE did not statistically significantly differ from referent values of healthy children.
These values changed in time in treated patients between the 1st and 3rd year at a significance level of 1 ‰.
IgG and IgA in treated patients were, in median, entirely within the values of normality. In the period after 1
year, we found significant correlations of umbilical IgE with serum IgE, IgG, IgA and correlation of serum
IgG with IgA. Very favourable effects of therapy on sickness rate of children compared to control group in a
predefined file of the same age period is shown graphically.