Application of silica nanopowder (15 nm) supported by potassium hydrogen sulphate has been demonstrated
to be an effective recyclable catalyst system for the opening of terminal epoxide ring using alcohol and/or
amine nucleophiles regioselectively at the terminal position in 3 hours at external temperature 70 °C. The terminal
insertion of nucleophile has also been observed with potassium bisulphate supported on silica fume surface having
particle size 100-150 nm with moderate products yield. Under this mild condition, no extra solvent is required
Keywords: Denopamine, epoxides, nucleophile, potassium hydrogen sulphate, silica fume.
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