Coronary heart disease is the leading cause of mortality worldwide, affecting millions of men and women every
year. Elucidation of key signaling factors and their pathways are critical for understanding and developing novel
therapeutic targets for protection of the myocardium from ischemia. EGR-1, an immediate early gene and a zinc finger
transcription factor plays critical role in various cardiovascular patho-biological processes. This article reviews the
growing evidence implicating EGR-1 pathway in myocardial ischemia/reperfusion, cardiac hypertrophy and other
cardiovascular complications like atherosclerosis.
Keywords: Atherosclerosis, EGR-1, ischemia/reperfusion injury, myocardial cell death, myocardial infarction, oxidative stress,
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