Common Variants for Heart Failure

Author(s): Shutong Shen , Lichan Tao , Xiuzhi Wang , Xiangqing Kong , Xinli Li .

Journal Name: Current Genomics

Volume 16 , Issue 2 , 2015

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Abstract:

Heart failure (HF) is a common disease with high morbidity and mortality; however, none of the drugs available are now entirely optimal for the treatment of HF. In addition to various clinical diseases and environment influences, genetic factors also contribute to the development and progression of HF. Identifying the common variants for HF by genome-wide association studies will facilitate the understanding of pathophysiological mechanisms underlying HF. This review summarizes the recently identified common variants for HF risk and outcome and discusses their implications for the clinic therapy.

Keywords: Common variants, Dilated cardiomyopathy, Genome-wide association studies, Heart failure, Mortality, Risk.

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2015
Page: [82 - 87]
Pages: 6
DOI: 10.2174/1389202916999150120153141
Price: $58

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