A Green and Efficient One-pot Synthesis of 1,2,3-Trisubstituted Pyrroles via Iodine-catalyzed Tandem Reaction

Author(s): Pengfei Xu , Kunzhu Huang , Dongsheng Cao , Wenbin Zeng .

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 4 , 2015

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Abstract:

A green, efficient and operationally simple method for three-component synthesis of 1,2,3- trisubstituted pyrrole derivatives via an iodine-catalyzed tandem reaction has been developed, and a series of 1,2,3-trisubstituted pyrrole derivatives were synthesized from simple starting materials under neutral conditions, with good to excellent yields in short time. This method showcased the potential of great value as a mild, rapid, and general procedure for the synthesis of 1,2,3-trisubstituted pyrroles.

Keywords: 1, 2, 3-Trisubstituted pyrrole, iodocyclization, multicomponent reaction (MCR), tandem reaction.

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Article Details

VOLUME: 12
ISSUE: 4
Year: 2015
Page: [290 - 298]
Pages: 9
DOI: 10.2174/1570178612666150119232103
Price: $58

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