Strategies and Methods for the Synthesis of Anticancer Natural Product Neopeltolide and its Analogs

Author(s): Yu Bai, Mingji Dai.

Journal Name: Current Organic Chemistry

Volume 19 , Issue 10 , 2015

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Abstract:

Neopeltolide, isolated in 2007, with its novel structural features and potent anti-cancer cell proliferation activity, has attracted a tremendous amount of synthetic efforts. This review briefly and chronologically summarizes each synthesis with the main focus on the strategies and methodologies for the construction of its cistetrahydropyran- containing macrolactone core.

Keywords: Anticancer, carbonylation, macrolactone, neopeltolide, palladium, tetrahydropyran.

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Article Details

VOLUME: 19
ISSUE: 10
Year: 2015
Page: [871 - 885]
Pages: 15
DOI: 10.2174/1385272819666150119225149
Price: $58

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