Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease that occurs throughout the
world with no racial, ethnic or socioeconomic boundaries. Despite its high morbidity and mortality, there are limited
medications available for ALS that may increase survival in patients with amyotrophic lateral sclerosis by approximately
2-3 months. Inasmuch as negative effects of riluzole on muscle atrophy and wasting, weakness, muscle spasticity,
dysarthria, dysphagia, and overall patient quality of life and its different adverse effects, much attention has been paid to
natural products and herbal medicines. Overall scientific reports indicate that natural products have beneficial effects on
patients with ALS low side effects and multiple targets. In the present paper, we review the scientific reports on beneficial
role of natural polyphenolic compounds in treatment of ALS.