Inflammatory bowel disease (IBD) is an idiopathic chronic, relapsing inflammation of the
bowel which is caused by dysregulation of the mucosal immune system. Polyphenols as the secondary
plant metabolites universally present in vegetables and fruits and are the most abundant antioxidants in the human diet.
There is evidence demonstrating the beneficial health effects of dietary polyphenols. This review criticizes the potential of
commonly used polyphenols including apple polyphenol, bilberry anthocyanin, curcumin, epigallocatechin-3-gallate
(EGCG) and green tea polyphenols, naringenin, olive oil polyphenols, pomegranate polyphenols and ellagic acid, quercetin,
as well as resveratrol specifically in IBD with an emphasis on cellular mechanisms and pharmaceutical aspects. Scientific
research confirmed that dietary polyphenols possess both protective and therapeutic effects in the management of
IBD mediated via down-regulation of inflammatory cytokines and enzymes, enhancing antioxidant defense, and suppressing
inflammatory pathways and their cellular signaling mechanisms. Further preclinical and clinical studies are needed in
order to understand safety, bioavailability and bioefficacy of dietary polyphenols in IBD patients.