MicroRNA Landscape in Alzheimer’s Disease

Author(s): Carlo Cogoni, Francesca Ruberti, Christian Barbato.

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 14 , Issue 2 , 2015

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Abstract:

Individual microRNAs and/or microRNA signatures were associated with Alzheimer’s disease (AD). We report here the recent advances brought to the identification of microRNA changes in AD brain and their biological function in the molecular pathways associated with the disease. This field represents a fertile route to understand the pathogenic mechanisms underlying Alzheimer’s disease. In addition we review recent studies aimed to discover promising biomarkers for AD diagnosis by microRNA expression profiles of biofluids from AD patients.

Keywords: Alzheimer’s disease, APP, microRNAs, tau.

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Article Details

VOLUME: 14
ISSUE: 2
Year: 2015
Page: [168 - 175]
Pages: 8
DOI: 10.2174/1871527314666150116123305
Price: $58

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