Amyotrophic Lateral Sclerosis: A Role for Non-Neuronal Cells
Pp. 205-222 (18)
Ana G. Barbeito
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder
characterized by the progressive degeneration of both upper and lower motor neurons
leading to paralysis and finally to death. Non-neuronal cells, including glial cells, have
been shown to actively participate in the physiopathological process occurring in ALS.
Experiments using chimeric mice expressing ALS-linked mutations suggest that
neighboring non-neuronal cells modulate disease phenotype. In this review, recent
findings involving the role of astrocytes, microglia and of other non-neuronal cells will
be discussed. The study of motor neuron microenvironment could lead to a better
understanding of the physiopathology of ALS to find new pathways to slow down
motor neuron degeneration.
Amyotrophic lateral sclerosis, ALS, amyotrophia, animal models,
astrocytes, CNS, glial cells, microglia, motor neuron, motor neuron disease,
neurodegeneration, neuroinflammation, neuroprotection, neurotoxicity, non-cell
autonomous, non-neuronal cells, progressive paralysis, SOD1, spinal cord,
Institut Pasteur de Montevideo, Laboratorio de Neurodegeneración, Mataojo 2020, Montevideo 11400, Uruguay.