Young Perspectives for Old Diseases

Indexed in: EBSCO

Young Perspectives for Old Diseases is a collaborative monograph describing the current understanding of common neurodegenerative diseases. The monograph focuses on the molecular and cellular ...
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Mitochondrial Dysfunction and Free Radicals in Neuronal Death

Pp. 119-132 (14)

Célia Harumi Tengan and Gabriela Silva Rodrigues

Abstract

Mitochondria are key organelles with a critical role as the main source of energy supply. Mitochondrial dysfunction can lead to several disorders, including neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases and the aging process. The mitochondrial respiratory chain is the main source of reactive oxygen species and because it is located in the inner mitochondrial membrane, it is also susceptible to oxidative damage, as well as other biomolecules in the vicinity, such as mitochondrial DNA. Nitric oxide is also found in the mitochondrial matrix and is involved in physiological pathways such as induction of apoptosis and generation of nitrosative stress. In this review we will discuss the complex mechanisms involved in the relationship between mitochondrial dysfunction, oxidative stress and neuronal death.

Affiliation:

Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, R. Pedro de Toledo, 781, São Paulo 04039-032, Brazil.