Calcium in Homeostasis and Neurodegeneration
Pp. 85-101 (17)
Flavio H. Beraldo and Ashbell Roy
All brain functions are controlled by specific synapses where the release of
neurotransmitters triggers a number of signaling cascades in postsynaptic neurons. One of
the most important and common events is a transient and very fast intracellular Ca2+
increase. Intracellular Ca2+ increase is fundamental for modulation of gene expression,
neuronal survival and plasticity. In this chapter we will discuss the importance of Ca2+ in
cells as well as the regulation of physiological functions in various organisms.
Additionally, we will consider mechanisms used by the cells for Ca2+ homeostasis and for
increasing intracellular Ca2+ concentration. Finally, the role of Ca2+ in neurodegenerative
diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Parkinson
disease (PD), Huntington disease (HD) among others will be discussed in this chapter.
Calcium, Alzheimer’s disease, Parkinson’s disease, Cellular signaling,
neurodegeneration, neurodegenerative diseases, brain, Inositol Trisphosphate,
Endoplasmic Reticulum, Voltage gated Ca2+ channels, glutamate receptors, ATP
receptors, Amyotrophic Lateral Sclerosis, Huntington’s Disease, Multiple Sclerosis,
SERCA pump, Ligand Ca2+ channels, Calcium Dysregulation, Ca2+-ATPase, Plasma
Robarts Research Institute, Western University, London, Ontario, Canada 1162 Smither RD, London, Ontario, Canada N6G5R8.