Homocoupling of arylboronic acids has been successfully carried out by using the inexpensive hydrophilic palladium(
II) complex PdCl2(NH2CH2COOH)2 as catalyst in i-PrOH/H2O (v/v=1:2) under aerobic atmosphere without elevated
heating to give rise to symmetrical biaryls in moderate to good yields. The aqueous media, room temperature reaction
and the low amounts of catalyst (0.5 mol%) show a practical and environmentally benign protocol. In addition, enhancement
of yield was observed in the presence of 0.5 equiv. p-toluenesulfonyl chloride. Furthermore, the byproducts of
this reaction were not observed while biaryl is the only product, which results in much more facile in the separation of the
product symmetrical biaryls from arylboronic acids.
Keywords: Hydrophilic catalyst, homocoupling of arylboronic acids, aqueous media, green chemistry.
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