A P-Ligand-Free Nickel-Catalyzed Variation of the Hirao Reaction Under Microwave Conditions

Author(s): Erzsebet Jablonkai, Laszlo B. Balazs, Gyorgy Keglevich.

Journal Name: Current Organic Chemistry

Volume 19 , Issue 2 , 2015

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Graphical Abstract:


The Hirao reaction, an important tool for the establishment of a P-C bond, was developed further by finding that the reaction of >P(O)H species, such as dialkyl phosphites, alkyl phenyl-H-phosphinates and diarylphosphine oxides with bromoarenes may be carried out in the presence of P-ligand-free NiCl2 as the catalyst. The scope and limitations of this “greener” approach was studied in detail.

Keywords: >P(O)H species, aryl bromides, Hirao reaction, microwave, Ni-catalyst, P-ligand-free.

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Article Details

Year: 2015
Page: [197 - 202]
Pages: 6
DOI: 10.2174/1385272819666150114235413

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