The maintenance of pancreatic β-cells normal functioning is crucial for insulin production and
glucose homeostasis. Inadequate insulin secretion due to β-cell dysfunction can lead to different types of
diabetes mellitus. Though it is widely recognized that both environmental and genetic factors play
important roles, the exact molecular mechanism that leads to β -cell failure is still unclear. MicroRNAs
(miRNAs) regulate numerous physiological and pathophysiological processes at the epigenetic level.
miRNAs have been reported to participate in the process of pancreatic development and insulin biosynthesis. Some
miRNAs may control insulin secretion and exocytosis through regulating ATP/ADP ratio. In this review, we will
summarize the pathological roles of miRNAs in β-cell dysfunction and briefly discuss miRNAs as possible biomarkers
and potential pharmaceutical target for diabetes mellitus.
Keywords: Biomarker, β cells, diabetes, insulin, miRNAs.
Rights & PermissionsPrintExport