Chronic Pain: Cytokines, Lymphocytes and Chemokines

Author(s): Marcia de Miguel, Durval Campos Kraychete, Roberto Jose Meyer Nascimento.

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)

Volume 13 , Issue 5 , 2014

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Abstract:

Chronic pain is a debilitating condition and, in most cases, difficult to treat. A prominent example of this is neuropathic pain. Understanding pathophysiological mechanisms of pain and, therefore, making this knowledge into an effective treatment is still a challenge to experts. Pain can now be considered as a neuro-immune disorder, since recent data indicate critical involvement of innate and adaptive immune responses following injury, and this interaction plays an important role in the onset and perpetuation of chronic pain. The aim of this article is to review the relationship between immune system and chronic pain, especially about neuropathic pain, and focusing on cytokines, chemokines and lymphocytes.

Keywords: Chemokines, chronic pain, cytokines, immune system, lymphocytes.

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2014
Page: [339 - 349]
Pages: 11
DOI: 10.2174/1871528114666150114170004
Price: $58

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