Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection

Author(s): Upinder Kaur, Priyanjalee Banerjee, Aritri Bir, Maitrayee Sinha, Atanu Biswas, Sasanka Chakrabarti.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 5 , 2015

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Abstract:

Oxidative stress and inflammatory response are important elements of Alzheimer's disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-κB and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-κBsignaling cascade has been discussed in the end.

Keywords: Alzheimer’s disease, Amyloid beta, Cytokines, NF-κB, Oxidative stress, Redox signaling.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2015
Page: [446 - 457]
Pages: 12
DOI: 10.2174/1568026615666150114160543
Price: $58

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