Striated muscle regeneration holds an intrinsic complexity governed by
many orchestrated events. When the fine balance of regulatory machineries is under
strain, the homeostatic conditions are lost and degeneration starts to occur. This is
the case for inherited and acquired diseases of both cardiac and skeletal muscles. A
wide range of factors are currently under scrutiny for better understanding the details
underlying de-/re-generation processes, of both genetic and non-genetic nature. This
review focuses on three classes of non-genetic factors regulating striated muscle regeneration,
i.e. microRNAs, signaling pathways and epigenetic regulators.
Keywords: Epigenetic factors, microRNAs, non-genetic factors, regeneration, signaling pathways, striated muscle.
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