In the past decades, tricyclic acridone ring system has become one of the major research interests of the
medicinal chemists due to the biological significance of this moiety in drug design and drug discovery. Acridone
scaffold has substantial bio-potential since it possess crucial activities such as antibacterial, antimalarial, antiviral
and anti-neoplastic. The diverse biological activity of acridone and its prospective in reversal of multi-drug
resistance has attracted attention of medicinal chemists to explore this scaffold especially to treat multi-drug
resistance in cancer. Considering this potential in this review we have summarized the synthesis and the antitumor activities of different
acridone derived compounds reported from 2000 to 2014.
Keywords: Acridone, antitumor, natural product, synthesis.
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