Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Recent Advance in Drug Development of Squamous Cell Carcinoma

Author(s): Jun Lei, Bing Fu, Hang Yin, Guanxiu Tang, Shujuan Zhu, Chunli Yan, Quanyong He.

Graphical Abstract:


Abstract:

Squamous cell carcinoma (SCC) has a high worldwide incidence that is commonly seen as head and neck cancers, esophageal cancers, and non-small cell lung cancers. There is a poor prognosis for SCC due to potential recurrence and its metastatic tendency so the 5-year survival rate is very low. Target therapy is a novel and promising treatment strategy exhibiting great anti-tumor effects and survival benefits in SCC. This review summarizes current treatment strategies from clinical and experimental studies, including the agents targeting epidermal growth factor receptors, RNA polymerase, toll-like receptors, p38α MAPK, CXCR, and the related combination therapy regimens. However, there are still many challenges we have to face. It is a burning need to improve the development and availability of drug formulations.

Keywords: Drug, epidermal growth factor receptor, esophageal, head and neck, lung, squamous cell carcinoma, target therapy, toll-like receptor.

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Article Details

VOLUME: 15
ISSUE: 7
Year: 2015
Page: [816 - 827]
Pages: 12
DOI: 10.2174/1871520615666150113103938
Price: $58