A facile and efficient synthesis of spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine] derivatives by one-pot reactions
of isatins, 2,6-diaminopyrimidin-4-one or 6-aminopyrimidine-2,4-dione and malononitrile under microwave irradiation
conditions was investigated. This protocol has the virtue of short reaction time, high yields and easy work-up procedure.
Keywords: spiro[indoline-3, 5`-pyrido[2, 3-d]pyrimidine], microwave, multicomponent reactions.
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