Tubulin has picked up great focus as a major target in drug discovery and consequently, tubulin
inhibitors have pulling in a considerable attention as anticancer agents. Numerable naturally occurring agents
have focused on tubulin system act as an imperative target of cancer chemotherapy. Substantial number of
tubulin inhibitors has been discovered so far and these agents are classified as indicated by their interaction.
They are colchicine site binder, vinca- alkaloid related drugs and those interacting with the Taxol binding
site and functioning as stabilising agents. We review the recent advances in the advancement of tubulin interfering agents
and will render the current trend in the improvement of tubulin inhibitors as anticancer agents.
Keywords: Tubulins, Anticancer agents, Laulimalide, Macrolides, Chalcones, Spongistatin.
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