Anticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review

Author(s): Jagbir Gagoria, Prabhakar Kumar Verma, Anurag Khatkar.

Journal Name: Central Nervous System Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

Volume 15 , Issue 1 , 2015

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Abstract:

From last few years research work on heterocyclic compound and their derivatives has been increasing. Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. As a small molecule, it contains electronegative atoms due to which it is feasible for other moieties to form conjugates. Referring to the bioorganic and medicinal chemistry, the moiety has potential to give active pharmacophores to develop new therapeutically important compounds. Benzothiazole derivatives were found to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, neuropathic pain, infectious diseases, epilepsy etc. In the present review, antiepileptic profile of benzothiazole derivatives is emphasized.

Keywords: Anticonvulsant, antiepileptic, benzothiazole, MES, neurotoxicity, PTZ.

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Article Details

VOLUME: 15
ISSUE: 1
Year: 2015
Page: [11 - 16]
Pages: 6
DOI: 10.2174/1871524915666150112094206

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