There is a close association of chronic tissue damage, inflammation and cancer. A chronic injury
may contribute to sustained healing response leading to fibrosis, organ failure and carcinogenesis.
Wounds created due to mechanical or patho-physiological insults, generally follow a sophisticated series
of mutually coherent steps leading to the re-establishment of the affected tissue or organ. The process of
wound healing resembles fundamental processes like embryogenesis and tissue regeneration. All the stages
in the wound healing process are tightly regulated and any sort of imbalance may lead to either non healing
chronic ulcers or excessively healed hypertrophic scars. Diabetic wounds are also very tough to heal and in many cases
they do not heal, ultimately resulting in the amputation of that body part. The non-healing property of diabetic wounds
may be due to combined effect of intrinsic and extrinsic factors. In this review, we aimed to explore the steps involved in
diabetic wound healing and compare it with the process of carcinogenesis. This review demonstrates that both carcinogenesis
and the diabetic wound healing follow a similar path of latent healing in an abnormal exaggerated manner.
Keywords: Diabetic wounds, carcinogenesis, inflammation, platelet aggregation, infection, microenvironment.
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