Abstract
A personalized approach for prediabetes and diabetes detection is presented, with its rationale and implications. Type 2 diabetes (T2DM) detection is particularly suitable to a personalized approach since the essence of its diagnosis is the identification of individuals who are at most risk of developing complications of the disease and who may benefit from intervention. Thresholds of glucose parameters for T2DM diagnosis have decreased over the years, as levels considered normal have been found to confer risks of complications. A continuum of glucose parameters, rather than universal thresholds, seems to better reflect the risks of diabetes and its complications. Individual trajectories of progression to diabetes suggest the possibility of establishing personalized profiles based on serial measurements. Demographic, clinical, genetic, and environmental factors need also be considered. Different diagnostic criteria are found to identify different phenotypes of T2DM. A personalized approach is needed to apply the accumulating knowledge to the recognition of individual risk for diabetes complications and effective interventions.
Keywords: High risk, profile, type-2 diabetes, lifestyle, hyperinsulinemia, fasting glucose, trajectories, metabolic syndrome.
Current Diabetes Reviews
Title:The Personalized Approach for Detecting Prediabetes and Diabetes
Volume: 12 Issue: 1
Author(s): Rachel Dankner and Jesse Roth
Affiliation:
Keywords: High risk, profile, type-2 diabetes, lifestyle, hyperinsulinemia, fasting glucose, trajectories, metabolic syndrome.
Abstract: A personalized approach for prediabetes and diabetes detection is presented, with its rationale and implications. Type 2 diabetes (T2DM) detection is particularly suitable to a personalized approach since the essence of its diagnosis is the identification of individuals who are at most risk of developing complications of the disease and who may benefit from intervention. Thresholds of glucose parameters for T2DM diagnosis have decreased over the years, as levels considered normal have been found to confer risks of complications. A continuum of glucose parameters, rather than universal thresholds, seems to better reflect the risks of diabetes and its complications. Individual trajectories of progression to diabetes suggest the possibility of establishing personalized profiles based on serial measurements. Demographic, clinical, genetic, and environmental factors need also be considered. Different diagnostic criteria are found to identify different phenotypes of T2DM. A personalized approach is needed to apply the accumulating knowledge to the recognition of individual risk for diabetes complications and effective interventions.
Export Options
About this article
Cite this article as:
Dankner Rachel and Roth Jesse, The Personalized Approach for Detecting Prediabetes and Diabetes, Current Diabetes Reviews 2016; 12 (1) . https://dx.doi.org/10.2174/1573399811666150109121219
DOI https://dx.doi.org/10.2174/1573399811666150109121219 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
Call for Papers in Thematic Issues
Advancing Diabetic Wound Healing: Mechanisms and Interventions
In recent years, diabetic wounds have become a global health concern with the increase in the incidence of diabetes. Diabetic wounds are a kind of chronic and refractory ulcer. It is generally due to the microcirculatory disturbances and the reduced levels of endogenous growth factors. Delayed cutaneous wound healing is ...read more
Oxidative and inflammatory responses in the development of secondary diabetic complications
Diabetes, along with its associated secondary complications, represents a significant global health challenge, contributing significantly to morbidity and mortality. Unhealthy lifestyle habits, reduced physical activity, environmental pollutants, and stress are pivotal factors in the onset of diabetes, particularly type-2 diabetes. Poorly managed hyperglycemia can lead to various complications, including neuropathy, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Update of QSAR & Docking Studies of the GSK-3 Inhibitors
Current Bioinformatics Vitamin D: A Pleiotropic Hormone with Possible Psychotropic Activities
Current Medicinal Chemistry Skeletal Myoblasts for Heart Regeneration and Repair: State of the Art and Perspectives on the Mechanisms for Functional Cardiac Benefits
Current Pharmaceutical Design <i>Larrea tridentata</i> and its Biological Activities
Current Topics in Medicinal Chemistry Highly Selective MEK Inhibitors
Current Enzyme Inhibition <i>In Silico</i> Design, Synthesis and Evaluation of Hydroxyxanthone Derivatives as Potential Anti-diabetic Agents Targeting α-glucosidase
Current Enzyme Inhibition Oral Angiotensin-(1-7) Peptide Modulates Intestinal Microbiota Improving Metabolic Profile in Obese Mice
Protein & Peptide Letters Influence of Hormones on Sjögren’s Syndrome
Current Pharmaceutical Design Adiponectin: Merely a Bystander or the Missing Link to Cardiovascular Disease?
Current Topics in Medicinal Chemistry Clinical Trials for Neuroprotection in ALS
CNS & Neurological Disorders - Drug Targets Clomiphene Citrate, Metformin or Both for Ovulation Induction in Therapy Naïve Women with Polycystic Ovary Syndrome (PCOS)? A Descriptive Review
Current Drug Therapy Overview of the Recent Advances in Pathophysiology and Treatment for Autism
CNS & Neurological Disorders - Drug Targets Interaction between Basic 7S Globulin and Leginsulin in Soybean [Glycine max]: A Structural Insight
Letters in Drug Design & Discovery A Review of Premature Frailty in HIV-Infected Persons; Another Manifestation of HIV-Related Accelerated Aging
Current Aging Science Survival Benefits of N-Acetylcysteine in Rodenticide Poisoning: Retrospective Evidence from an Indian Tertiary Care Setting
Current Reviews in Clinical and Experimental Pharmacology “Early” or Timely Discharge in Kangaroo Mother Care: Evidence and Experience
Current Women`s Health Reviews The Hypocretins and their Role in Narcolepsy
CNS & Neurological Disorders - Drug Targets Prevention and Treatment of Diabetic Retinopathy: Evidence from Clinical Trials and Perspectives
Current Diabetes Reviews Cyclodextrin-based Materials for Removing Micropollutants From Wastewater
Current Organic Chemistry Recent Progress in the Development of ATP-Competitive and Allosteric Akt Kinase Inhibitors
Current Topics in Medicinal Chemistry