Naturally occurring organic acids are reported to be highly efficient promoters for the Biginelli reaction under
thermal and microwave irradiation using solvent free conditions. Among the various organic acids used, malic acid was
found to be the most effective promoter for Biginelli reaction under above reaction conditions. Present protocol is a simple
and eco-friendly route for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones.
Keywords: Biginelli reaction, 3, 4-dihydropyrimidin-2(1H)-ones/thiones, naturally occurring acid, green promoters, solventfree
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