Natural Organic Acids Promoted Synthesis of 3, 4-Dihydropyrimidin- 2(1H)-ones/thiones Under Solvent-free Conditions

Title:Natural Organic Acids Promoted Synthesis of 3, 4-Dihydropyrimidin- 2(1H)-ones/thiones Under Solvent-free Conditions

Volume: 12 Issue: 3

Author(s): Nitin M. Thorat and Shankar R. Thopate

Affiliation:

Keywords: Biginelli reaction, 3, 4-dihydropyrimidin-2(1H)-ones/thiones, naturally occurring acid, green promoters, solventfree synthesis.

Abstract: Naturally occurring organic acids are reported to be highly efficient promoters for the Biginelli reaction under thermal and microwave irradiation using solvent free conditions. Among the various organic acids used, malic acid was found to be the most effective promoter for Biginelli reaction under above reaction conditions. Present protocol is a simple and eco-friendly route for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones.

Cite this article as:

Thorat M. Nitin and Thopate R. Shankar, Natural Organic Acids Promoted Synthesis of 3, 4-Dihydropyrimidin- 2(1H)-ones/thiones Under Solvent-free Conditions, Letters in Organic Chemistry 2015; 12 (3) . https://dx.doi.org/10.2174/1570178612666150108003629