Design and Efficient Synthesis of Some Azole and Thiazole Systems Based 3-(1,3-Dioxoisoindolin-2-yl)-3-oxopropanenitrile

Author(s): Islam Helmy El Aazab, Fawi Mohamed Abd El Latif.

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 3 , 2015

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Abstract:

A variety of pyrazoles, thiazoles, thiadiazoles, thiazolidines, azetidine, thiazolo[3,2-a]pyrimidine and pyrazolo[3,4-b]pyridine systems, based on 3-(1,3-dioxoisoindolin-2-yl)-3-oxopropanenitrile precursor are synthesized in good yields. The mechanistic aspect for the formation of the newly synthesized compounds is discussed and the structure of the synthesized compounds was established based on elemental analysis and spectral data.

Keywords: Azole, thiazole, phthalimide, pyrazole, enaminonitrile, 1, 3-dioxoisoindoline.

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2015
Page: [187 - 196]
Pages: 10
DOI: 10.2174/1570178612666150108001531
Price: $58

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