Synthesis of the Major Metabolites of Febuxostat

Author(s): Xiao Long Li , Rui Qiu , Wei Li Wan , Xu Cheng , Li Hai , Yong Wu .

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 3 , 2015

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Abstract:

Total synthesis of three Febuxostat metabolites, named 67M-1, 67M-2, and 67M-4,is described in this article. Through condensation of the key intermediate compound A with different side chains, and then oxidation and hydrolysis, we obtained three target compounds with an overall yield of 19.5%-28.0%.

Keywords: Febuxostat, three metabolites, total synthesis.

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2015
Page: [217 - 221]
Pages: 5
DOI: 10.2174/1570178612666150108000805
Price: $58

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