Abstract
Cancer cell metabolism plays an important role in the progression of lung cancer. It is characterized through a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon referred to as the warburg effect. However, the deregulation of miRNAs contributing to the warburg effect and to cancer cell metabolism is still unknown. In the present study, the results demonstrate that the expression of miR-202 is significantly decreased, and it induces a metabolic shift in lung cancer cells. miR-202 exerts this function through targeting HK2, resulting in the increase of glucose uptake and lactate production. The altered metabolism induced by miR-202 leads to cancer cell growth. These studies demonstrated that miR-202 may be involved in the metabolic shift via targeting HK2 in lung cancer cells.
Keywords: HK2, lung cancer, miR-202.
Current Signal Transduction Therapy
Title:miR-202 Mediates Metabolic Shift in Lung Cancer Cells via Targeting HK2
Volume: 9 Issue: 2
Author(s): Jin Li, Baohua Zhang, Qihuang Chen and Qiang Li
Affiliation:
Keywords: HK2, lung cancer, miR-202.
Abstract: Cancer cell metabolism plays an important role in the progression of lung cancer. It is characterized through a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon referred to as the warburg effect. However, the deregulation of miRNAs contributing to the warburg effect and to cancer cell metabolism is still unknown. In the present study, the results demonstrate that the expression of miR-202 is significantly decreased, and it induces a metabolic shift in lung cancer cells. miR-202 exerts this function through targeting HK2, resulting in the increase of glucose uptake and lactate production. The altered metabolism induced by miR-202 leads to cancer cell growth. These studies demonstrated that miR-202 may be involved in the metabolic shift via targeting HK2 in lung cancer cells.
Export Options
About this article
Cite this article as:
Li Jin, Zhang Baohua, Chen Qihuang and Li Qiang, miR-202 Mediates Metabolic Shift in Lung Cancer Cells via Targeting HK2, Current Signal Transduction Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574362410666150107234535
DOI https://dx.doi.org/10.2174/1574362410666150107234535 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Transdermal Penetration of Cytarabine and Its 5-O Alkyl Ester Derivatives
Medicinal Chemistry Potential Disease Targets for Drugs that Disrupt Protein - Protein Interactions of Grb2 and Crk Family Adaptors
Current Pharmaceutical Design Current Approaches to Diagnostics and Therapies of Chronic Diseases: Focus on Molecular and Cell Biology
Current Pharmaceutical Design VEGF/VEGFR Pathway Inhibitors as Anti-Angiogenic Agents: Present and Future
Current Cancer Drug Targets Exploring siRNA Umpired Nanogels: A Tale of Barrier Combating Carrier
Current Pharmaceutical Design Efficacy and Toxicological Studies of Cremophor EL Free Alternative Paclitaxel Formulation
Current Drug Safety Role of Netrin-1 Beyond the Brain: From Biomarker of Tissue Injury to Therapy for Inflammatory Diseases
Recent Patents on Biomarkers Targeting Receptor Tyrosine Kinases Using Monoclonal Antibodies: The Most Specific Tools for Targeted-Based Cancer Therapy
Current Drug Targets The Enzymology of Cytosolic Pyrimidine 5’-Nucleotidases: Functional Analysis and Physiopathological Implications.
Current Medicinal Chemistry Cloning, Expression and Characterization of Mouse (Mus musculus) Nicotinamide 5-Mononucleotide Adenylyltransferase-2
Medicinal Chemistry Development of Lymphatic Vessels: Tumour Lymphangiogenesis and Lymphatic Invasion
Current Medicinal Chemistry Xanthohumol, a Prenylated Chalcone Derived from Hops, Suppresses Cancer Cell Invasion through Inhibiting the Expression of CXCR4 Chemokine Receptor
Current Molecular Medicine Screening of Hub Gene Targets for Lung Cancer via Microarray Data
Combinatorial Chemistry & High Throughput Screening Targeting BMP9-Promoted Human Osteosarcoma Growth by Inactivation of Notch Signaling
Current Cancer Drug Targets Peripheral Benzodiazepine Receptor (PBR) New Insight in Cell Proliferation and Cell Differentiation Review
Current Clinical Pharmacology Fungal Bioactive Compounds in Pharmaceutical Research and Development
Current Bioactive Compounds Exploration and Exploitation of the Yeast Volatilome
Current Metabolomics PET Imaging of the Peripheral Benzodiazepine Receptor: Monitoring Disease Progression and Therapy Response in Neurodegenerative Disorders
Current Pharmaceutical Design Synthesis of Marine Natural Products with Antimalarial Activity
Mini-Reviews in Medicinal Chemistry Therapeutic Immunoconjugates. Which Cytotoxic Payload: Chemotherapeutic Drug (ADC) or Radionuclide (ARC) ?
Current Cancer Therapy Reviews