OPA1 in Cardiovascular Health and Disease

Author(s): Niall Burke, Andrew R. Hall, Derek J. Hausenloy.

Journal Name: Current Drug Targets

Volume 16 , Issue 8 , 2015

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Abstract:

Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.

Keywords: Cardiovascular disease, fission, fusion, mitochondrial morphology, OPA1.

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2015
Page: [912 - 920]
Pages: 9
DOI: 10.2174/1389450116666150102113648
Price: $58

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