Recent Trends of Chalcones Potentialities as Antiproliferative and Antiresistance Agents
Attilio Di Pietro,
Tânia B. Creczynski-Pasa.
Chalcones are natural compounds found in plants, fruits and vegetables. This class of compounds has
shown many biological activities including antioxidant, antimicrobial, anti-inflammatory, antifungal and
antihypertensive, among others. In cancer, it has been reported that chalcones interfere in several points of the
signal transduction pathways related to cellular proliferation, angiogenesis, metastasis, apoptosis and the reversal
of multidrug resistance. The large number of research articles and patents related to chalcones is already an
indication of their importance as a lead class of compounds. This article gathers recent efforts to elucidate the
molecular mechanisms of action of chalcones, associated with their anticancer and anti resistance potential.
Keywords: Apoptosis, cancer, chalcones, cytotoxicity, drug-efflux pump inhibitors, multidrug resistance.
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