Diabetes mellitus (DM), an increasing health problem worldwide, is associated with severe cardiovascular
complications. To date, the beneficial effects of physical activity in both prevention and treatment of DM and its complications
are well established. Nevertheless, it appears that exercise training, depending on the load, exerts differential effects
on the myocardium. Hence, in this review, the impact of exercise training, focusing on exercise modalities and adaptations
in response to load, on diabetic cardiovascular function, are discussed. Molecular mechanisms that may be involved
in these adaptions to exercise training are also addressed.