Among the various parasitic diseases, malaria is the deadliest one. Due to the emergence of
high drug resistance to the existing drug candidates there is a global need for development of new drug
candidates which will be effective against resistant strains of malaria parasite. In silico molecular
modeling approaches have been playing an important role in the discovery of novel lead molecules
having antimalarial activity. Present review is an effort to cover all the developments related to the
application of computational techniques for the design and discovery of novel antimalarial compounds
since the year 2011 onwards.
Keywords: Antimalarial agents, drug resistance, docking, homology model, malaria, pharmacophore, QSAR, virtual screening.
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