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Current Aging Science

Editor-in-Chief

ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

Reference Database of Lung Volumes and Capacities in Wistar Rats from 2 to 24 Months

Author(s): Wilson Jacob Filho, Renata Gabriel Fontinele and Romeu Rodrigues de Souza

Volume 7, Issue 3, 2014

Page: [220 - 228] Pages: 9

DOI: 10.2174/1874609808666141229114508

Price: $65

Abstract

This study determines the effects of growing and aging on lung physiological volumes and capacities and the incidence of inflammation in the small airways with age in rats. A reference database comprising of body weight gain, lung physiological volumes and capacities and an anatomopathological study of lung lesions over 240 Wistar rats from two to 24 -mo, is described. Tidal volume (TV), minute respiratory volume (MRV), and forced vital capacity (FVC) decreased during the first six months of life and then remain constant until 24 -mo of age. The respiratory frequency (Rf) and dynamical compliance (Cdyn) maintain at constant values from 2 to 24- mo of age; the functional residual capacity (FRC) increases in the first 6 -mo and then remains constant up to 24 -mo. It was verified a less intensive inflammation in the small airways with age, when compared with the median and large airways. In conclusion: This study showed the normal parameters for lung volumes and capacities and the incidence of infections for growing and aging male and female rats. The age-related data on these main respiratory parameters in rats would be useful in studies of aging-related disorders using this model and for safety pharmacology studies necessary for the development of drugs.

Keywords: Aging, anatomopathological data, lung function, plethysmography, respiratory parameters, mus muris.


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