Reference Database of Lung Volumes and Capacities in Wistar Rats from 2 to 24 Months

Author(s): Wilson Jacob Filho, Renata Gabriel Fontinele, Romeu Rodrigues de Souza.

Journal Name: Current Aging Science

Volume 7 , Issue 3 , 2014

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This study determines the effects of growing and aging on lung physiological volumes and capacities and the incidence of inflammation in the small airways with age in rats. A reference database comprising of body weight gain, lung physiological volumes and capacities and an anatomopathological study of lung lesions over 240 Wistar rats from two to 24 -mo, is described. Tidal volume (TV), minute respiratory volume (MRV), and forced vital capacity (FVC) decreased during the first six months of life and then remain constant until 24 -mo of age. The respiratory frequency (Rf) and dynamical compliance (Cdyn) maintain at constant values from 2 to 24- mo of age; the functional residual capacity (FRC) increases in the first 6 -mo and then remains constant up to 24 -mo. It was verified a less intensive inflammation in the small airways with age, when compared with the median and large airways. In conclusion: This study showed the normal parameters for lung volumes and capacities and the incidence of infections for growing and aging male and female rats. The age-related data on these main respiratory parameters in rats would be useful in studies of aging-related disorders using this model and for safety pharmacology studies necessary for the development of drugs.

Keywords: Aging, anatomopathological data, lung function, plethysmography, respiratory parameters, mus muris.

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Article Details

Year: 2014
Page: [220 - 228]
Pages: 9
DOI: 10.2174/1874609808666141229114508
Price: $58

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