Reference Database of Lung Volumes and Capacities in Wistar Rats from 2 to 24 Months
Wilson Jacob Filho,
Renata Gabriel Fontinele,
Romeu Rodrigues de Souza.
This study determines the effects of growing and aging on lung physiological volumes and capacities
and the incidence of inflammation in the small airways with age in rats. A reference database comprising
of body weight gain, lung physiological volumes and capacities and an anatomopathological study of lung
lesions over 240 Wistar rats from two to 24 -mo, is described. Tidal volume (TV), minute respiratory volume (MRV), and
forced vital capacity (FVC) decreased during the first six months of life and then remain constant until 24 -mo of age. The
respiratory frequency (Rf) and dynamical compliance (Cdyn) maintain at constant values from 2 to 24- mo of age; the functional
residual capacity (FRC) increases in the first 6 -mo and then remains constant up to 24 -mo. It was verified a less intensive
inflammation in the small airways with age, when compared with the median and large airways. In conclusion:
This study showed the normal parameters for lung volumes and capacities and the incidence of infections for growing and
aging male and female rats. The age-related data on these main respiratory parameters in rats would be useful in studies of
aging-related disorders using this model and for safety pharmacology studies necessary for the development of drugs.
Keywords: Aging, anatomopathological data, lung function, plethysmography, respiratory parameters, mus muris.
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