Controlled Release of Nafcillin Using Biocompatible “Dummy” Molecularly Imprinted Sol-Gel Nanospheres

Author(s): T. Diaz-Faes Lopez, M.A. Escudero Francos, A. Fernandez Gonzalez, M.E. Diaz-Garcia, R. Badia-Laino.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 3 , 2015

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Abstract:

Different silicon-based xero-gel molecularly imprinted spheres in the nano boundary range with recognition capabilities for nafcillin have been synthesised, using tetraethylorthosilicate (TEOS) and (3- aminopropyl) triethoxysilane (APTEOS) as precursors. Imprinting has been achieved using both nafcillin (NAF) or structural analogous ‘dummies’ such as (+)-6-aminopenicillenic acid (APA), or ampicillin ((+)-6- aminobenzylpenicillin)sodium salt (AMP). Materials were fully characterized using ATR-FTIR, 29Si solidstate NMR, TGA, TEM and BET. Adsorption isotherms for all the materials fit with a continuous Freundlich model with correlation coefficients better than 0.988 and mean affinity constants between 105 and 106 L·mol-1. The use of ‘dummies’ as well as the template itself in the imprinting process resulted in materials with different release speed. Combinations of these materials allow designing mixtures with a continuous, controlled and constant release longer than four days. Thus, the non-imprinted and the AMP-imprinted material have a rapid release during the first five hours, nafcillin and APA imprinted ones release antibiotic mainly after a latency-period of 24 hours.

Keywords: Adsorption, Drug Delivery, Isotherms, Molecularly imprinted silica, Nafcillin, Nanospheres.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2015
Page: [262 - 270]
Pages: 9
DOI: 10.2174/1568026614666141229113630
Price: $58

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